A recent legal case involving an ambiguous diagnosis in a woman with a severe disorder of consciousness raises pressing questions about treatment withdrawal in a time when much of what experts know about disorders of consciousness is undergoing revision and refinement. How much should diagnostic certainty about consciousness matter? For the judge who refused to allow withdrawal of artificial nutrition and hydration, it was dispositive. Rather than relying on substituted judgment or best interests to determine treatment decisions, he ruled that (...) withdrawal was categorically prohibited, even as he concluded that Hannah Capes was more likely than not in a permanent vegetative state. In many jurisdictions, his decision would likely be consistent with existing law. Evolving technological advances have demonstrated that biologically distinct diagnoses incorporated into state laws may be difficult to establish even under ideal conditions. We offer the Capes case for purposes of examining the consequences of enshrined legal distinctions between permanent vegetative state and other severe disorders of consciousness. Insistence on proof of the permanent absence of consciousness before treatment withdrawal is allowed fails to respect the rights of persons with disorders of consciousness. Even the well-established rights to treatment withdrawal for those in a permanent vegetative state may be in jeopardy if reform is not undertaken. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Largely neglected today, the work of Karl Philipp Moritz was a highly influential source for Early German Romanticism. Moritz considered the form of myth as essential to the absolute nature of the divine subject. This defence was based upon his aesthetic theory, which held that beautiful art was “disinterested”, or complete in itself. For Moritz, Myth, like art, constitutes a totality providing an idiom free from restriction in the imitation of the divine. This examination offers a consideration of Moritz’s aesthetics (...) and mythography, before turning briefly to consider his influence on the authors of Early German Romanticism. An understanding of the role of Moritz’s thought supports a number of recent claims that challenge the conventional reading of Romanticism. At the same time it allows us to see Romanticism’s unconventional realist theological programme, permitting us to overcome the problematic secularising readings of the movement. I would like to thank Kurt Mueller-Vollmer, as well as Fredrick Beiser and Lars Fischer for their help with this project. (shrink)

What is African American Politics? What form should it take? How does it conceptualize white supremacy? In In the Shadow of Du Bois, Robert Gooding-Williams uses the work of W. E. B. Du Bois and Fredrick Douglass to provide answers to these questions. While the choices of Douglass and Du Bois make a great deal of sense, they reproduce the tendency of confining political theory to literature – a move that bounds the genre in problematic ways. In this article, (...) I in effect attempt to “unbound” the genre by considering Ella Baker, a civil rights era political organizer. (shrink)

Routledge is proud to reissue these nine pivotal titles from the acclaimed series Studies in Ethics and the Philosophy of Religion. Including key works by Ahern, Beardsmore, Pike, and others, these books are essential for all serious collections. Available as single volumes or as a nine-volume set, the titles in this collection were originally published between 1950-1960 by Routledge and Kegan Paul: Volume 1: The Problem of Evil M.B. Ahern Hb: 0-415-31841-6 Volume 2: Moral Reasoning R.W. Beardsmore Hb:0-415-31842-4 Volume (...) 3: Theology and Intelligibility Michael Durrant Hb: 0-415-31843-2 Volume 4: Humanism and Ideology James R. Flynn Hb: 0-415-31844-0 Volume 5: The Five Ways: St.Thomas Aquinas' Proofs of God's Existence Anthony Kenny Hb: 0-415-31845-9 Volume 6: Moral Practices D.Z. Phillips Hb: 0-415-31846-7 Volume 7: God and Timelessness Nelson Pike Hb: 0-415-31847-5 Volume 8: Without Answers Rush Rhees Hb: 0-415-31848-3 Volume 9: Morality and Purpose J.L. Stocks Hb: 0-415-31849-1. (shrink)

Este artículo presenta los fonemas segmentales del mapudungun hablado en Icalma y un perfil fonético-fonológico de parte importante del cordón cordillerano de habla pewenche. El marco de referencia utilizado es el descriptivismo norteamericano, cuyas propuestas provienen de Pike y se actualizan en los trabajos de Burquest y Salamanca, Cifuentes y Figueroa. El instrumento utilizado fue una lista léxica de 108 ítems y la cantidad de colaboradores entrevistados fue de nueve. Con respecto a la descripción fonético-fonológica del mapudungun hablado en (...) la zona, destacan los siguientes resultados: a) predominan las realizaciones fricativas áfonas [ f ] y [ θ ]; b) los fonos interdentales [ t̟ ], [ n̟ ] y [ l̟ ], y el fono fricativo velar [ ɣ ], tienen estatus fonémico; y c) el fono [ ʃ ] no ocurre en la zona. Por otra parte, si se compara el mapudungun hablado en Icalma con el de Alto Bío-Bío, Lonquimay y Curarrehue, se aprecia, en general, una mayor afinidad con el mapudungun hablado en esta última zona. (shrink)

This essay reflects on 25 years since Christian Bioethics began publication and, in somewhat autobiographical fashion, engages two core concerns. First, although “non-ecumenism” may often appear a pretext for contention and division, I suggest that a respectful non-ecumenism may provide the opportunity for dialogue and the occasion for employing certain tools from religious studies. Second, although many are skeptical about the possibilities of identifying a “common morality,” a defense of that notion provides a plausible explanation for the development of limited (...) consensus on some issues in bioethics. (shrink)

This paper examines the standard conceptualizations of the notion of hallucination in light of various non-ordinary phenomenological patterns associated with altered states of consciousness induced by psychoactive agents. It is argued that in general, the conceptualizations encountered in the literature do not do justice to the richness and complexity that the psychological phenomenology actually exhibits. A close inspection of this phenomenology reveals some pertinent distinctions which are usually not made in the scientific literature. On the one hand, the discussion is (...) based on first-hand experiences and, on the other hand, it is grounded in empirical and theoretical cognitive investigations of the phenomenology of human consciousness. Theoretically, the discussion is grounded in an approach highlighting the centrality of experience, meaning and action in cognition. (shrink)

What is human reason, how did it arise, how is it connected to animal reason? In The Enigma of Reason (ER) Hugo Mercier and Dan Sperber (2017) suggest that reason evolved driven by the need to support communication and coordination in small human groups. They contrast this to the idea that the function of reason is to enable humans to make better decisions and develop more accurate beliefs. After a summation of the ER argument, the theory is critiqued and two (...) of their assumptions -- that human cognition is based on massive modularity and that reason co-evolved with and is dependent upon language -- are challenged. Alternatives to these assumptions are presented from the perspective of pattern matching processes in neural dynamical systems, which it is asserted provides a more realistic approach to the functioning of the brain and mind. (shrink)

Modern science developed in the interflow of culture between west and east. Combing of pratice technology with philosophic thoughts formed experimental method. Holistic views contacting atomism produced system theory. System thoughts are applicated in the science and engineering of biosystems, and the cencepts of system biomedicine (Kamada T.1992), systems biology (Zieglgansberger W, Tolle TR.1993), system bioengineering and system genetics (Zeng BJ. 1994) were established. From positive to synthetic thoughts, philosophy have been developed ontology, cosmology, organism theories. Structurity is structure logic (...) system founded on entity, develop, exist axioms, tolerance, adaptation, fluctuate, interweave, transform theorems and integrate, adaptation, construct laws. Structurity be discussed on the cosmos, life, culture system, creation, hologram theories of structure ontology, construct mutation, simi-structure organism and entity emergence, symbol implication. From the relation of structure, function and development, the structurity put forward the cycle, spiral, triangle structure stability patterns of self-organization in structure complement each other and stratification, functional couple and interflow bounds growth, coordinativetransformation and holographic symmetry. (shrink)